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Principal curvature postview8/2/2023 ![]() ![]() Taken together, our findings encourage an expansion of geometrical parameters considered for rupture risk assessment, and provide perspective on the degree to which tissue mechanical properties may modulate peak stress values within aneurysmal tissue.Ī significant manifestation of cardiovascular disease involves a regional dilation of the aorta termed an aortic aneurysm (AA). In this study, we use a series of finite element-based computational models that represent a range of plausible AA scenarios, and evaluate the relative sensitivity of wall stress to geometrical and mechanical properties of the aneurysmal tissue. Therefore, a pressing need remains to identify better predictors of rupture risk and ultimately integrate their measurement into clinical decision making. Despite established thresholds for intervention, rupture occurs in a notable subset of patients exhibiting sub-critical maximal diameters and/or growth rates. The decision to surgically intervene prior to AA rupture is made with recognition of significant procedural risks, and is primarily based on the maximal diameter and/or growth rate of the AA. Occurrence of AA rupture is an all too common event that is associated with high levels of patient morbidity and mortality. ![]() An aortic aneurysm (AA) is a focal dilatation of the aortic wall. ![]()
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